დიაცეტონ-D-მანოზის კონდენსაცია ანესთეზინთან და სინთეზირებული ნაერთის სავარაუდო ბიოლოგიური აქტიურობის დადგენა

In the series of carbohydrate derivatives, a significant number of substances have been found that are used in medicine as medicines for various purposes. Chemical modification of known drugs based on carbohydrates is one of the promising directions in the search for new biologically active substances. Modified derivatives of saccharides are now widely used in medicine, for example, as effective antiviral and anticancer drugs.
The goal of present investigation consist in synthesis of nitroso group containing Nmannosylamine and investigation of biological activity potential of synthesized substance.
The reaction condensation of Diacetone-D-mannose (1) with Ethyl Ether p-aminobenzoic acid we obtained − N-β-(p-aminobenzoic acid ethyl ester)-2,3;5,6-mannofuranosylamine (2). By interaction of obtained N-mannosylamines with sodium nitrite corresponding nitroso derivative Nβ-N-nitroso-(p-aminobenzoic acid ethyl ester)-2,3;5,6–di-O-izopropilidene-D-mannosylamine (3) has been received. The structures of obtained compounds were established by physical-chemical methods of analysis.
With the purpose of theoretical substantiation of the direction of the reactions of synthesis of glycosilamine quantum-chemical calculations were carried out using the semi-empirical AM1 method. With the help of computer program PASS Onlainis based on the analysis of structure activity-relationships wide range of possible biological activity and toxic / side effects for synthesized glycosolamines has been determined.