აზოტის ოქსიდის როლი ჰიპერჰომოცისტეინემიით განპირობებული არტერიული ვაზომოტორული რეაქციების დარღვევაში

It is known that a significant congenital disorder of homocysteine metabolism evokes blood
vessels disorder, but the mechanism of this damage development is still not well established.
Now, hyperhomocysteinemia is considered as an independent risk-factor of atherosclerotic
vascular disease.
The mechanism, by which hyperhomocysteinemia contributes the development of vascular
damage is still unknown. What is established can be shortly summarized in this way: an increased concentration of total homocysteinemia affects the endothelial cells. Their damage, the
activation of platelets, a damaging effect on thrombomodulin expression, the activation of tissue factor, an enhanced oxidativeness in low density lipid proteins – it is the list, in which any of
above-said may be considered as possible mechanisms, by means of which homocysteine leads to
atherosclerosis and thrombosis