ენანტიომერული ნარევების დაყოფა ზეკრიტიკული სითხეების ქრომატოგრაფიაში ქირალურ სელექტორად ცელულოზა ტრის (3-ქლორ-5მეთილფენილკარბამატის) გამოყენებით

Separation of enantiomers represents one of the hot topics of contemporary chemistry from both theoretical and practical points of view. The importance of this problem from the pracrical point of view is caused by the fact that enantiomers of chiral biologically active molecules such as pharmaceuticals, food additives, agrochemicals, etc., are commonly characterized with different target activity, toxicity, metabolism, transformation in environment, etc. For instance, enantiomers of chiral pesticides may have not only different effect on target object but may also undergo transformation with different speed and form different final degradation products due to enantioselective action of enzymes and microbs [1]. More than half of currently used drugs are chiral and waste majoriy of them are still used in a racemic form. This is not justified since the enantiomers of chiral drugs commonly possess different pharmacodynamic and pharmacokinetic properties [2]. Chirality represent very challenging issue on the way of development of new chiral drugs, agrochemicals, food additives and other biologically active molecules. Therefore, chirality, enantiomer separation and other related topics represent the objects of many international conferences (for instance, annual series of Chirality conference), dedicated journals (for instance journal Chirality from Wiley, New York, USA), books [3] and governmental regulations, such as US Food and Drug Administration (FDA), European Medical Agency (EMA), etc. Based on above mentioned, the most effective and safe use of chiral biologically active compounds requires separation of their enantiomers and reliable evaluation of their enantiomeric purity.