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GST გენების (GSTT1 და GSTM1) პოლიმორფიზმის კავშირი წამლებით გამოწვეულ ჰეპატოტოქსიკურობასთან ფილტვის ტუბერკულოზის დროს, ქართულ პოპულაციაში
Date Issued
2019
Author(s)
Advisor(s)
Institution
Abstract
Nowadays, the genetic study of the effectiveness of pharmacotherapy and its side effects is actively achived. The reason for the development of a significant part of hepatitis is the effect of medication.
The cause of hepatotoxicity of some drugs is the polymorphism of the genes encoding enzymes which are involved in the metabolism of these drugs. To the number of these enzymes belongs to Glutathiones-Transferase (GST). GST plays a vital role in II phase biotransformation and detoxification of many artificially produced compounds, including drugs. GSTs are polymorphic and they are characterised by ethno-dependency associated with various diseases. One of these diseases is tuberculosis.
Liver damage caused by anti tuberculosis drugs causes a lot of side effects in the treatment of disease.
Thus, it is necessary to take into account genotypic differences during treatment with antituberculotic drugs in order to reduce the risk of liver damage caused by preparations.
The cause of hepatotoxicity of some drugs is the polymorphism of the genes encoding enzymes which are involved in the metabolism of these drugs. To the number of these enzymes belongs to Glutathiones-Transferase (GST). GST plays a vital role in II phase biotransformation and detoxification of many artificially produced compounds, including drugs. GSTs are polymorphic and they are characterised by ethno-dependency associated with various diseases. One of these diseases is tuberculosis.
Liver damage caused by anti tuberculosis drugs causes a lot of side effects in the treatment of disease.
Thus, it is necessary to take into account genotypic differences during treatment with antituberculotic drugs in order to reduce the risk of liver damage caused by preparations.
Degree Name
ბიოლოგიის მაგისტრი (ბიომრავალფეროვნება, ბიოქიმია; ნეირომეცნიერებები; განვითარების ბიოლოგია; მცენარეთა ფიზიოლოგია; მიკრობიოლოგია; იმუნოლოგია; უჯრედული ბიოლოგია, მოლეკულური ბიოლოგია; გენეტიკა; ბიოფიზიკა). MSc in Biology (Biodiversity; Biochemistry; Neurosciences, Developmental Biology; Plant Physiology, Microbiology; Imunology; Cellular biology; Molecular Biology; Genetics, Biophysics)
Degree Discipline
ბიოლოგია. Biology
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MA Thesis Xujadze Inga.pdf
Description
GST გენების (GSTT1 და GSTM1) პოლიმორფიზმის კავშირი წამლებით გამოწვეულ ჰეპატოტოქსიკურობასთან ფილტვის ტუბერკულოზის დროს, ქართულ პოპულაციაში
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1.05 MB
Format
Adobe PDF
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(MD5):de121eec6179e0c077e1987780097abe