ნიტროზო ჯგუფის შემცველი D-გალაქტოპირანოზილამინის სინთეზი და ბიოლოგიური აქტიურობის შესწავლა

It is known that nitric oxide is involved in many physiological and pathological processes. It acts as a vasodilator, participates in the function of the immune system, the nervous system, regulates apoptosis and cell proliferation. In this respect, the synthesis of Nitroso (N = O) group containing carbohydrate derivatives and study of their biological activity is a promising research direction to obtain new type biologically and pharmacologically active compounds.
The formation of N-β-(p-tolyl)-galactosylamine (II) by condensation of D-galactose with ptoluidine was studied at the first stage. By acetilation and further nitrozilation of Naryllactosylamine corresponding N-β-N-nitroso-(p-tolyl)-2,3,4,6-tetra-O-acetyl-D-galactosyl-amine (IV) has been obtained at the first time.
The structures of obtained compounds were established by physical-chemical methods of analysis.
With the purpose of theoretical substantiation of the direction of the reactions of synthesis of N-p-tolyl-β-D-galactopyranosylamine quantum-chemical calculations were carried out using the semi-empirical AM1 method. With the help of computer program PASS Onlainis based on the analysis of structure activity-relationships wide range of possible biological activity and toxic / side effects for synthesized glycosolamines has been determined.