ქლორფენირამინის ენანტიომერების დაყოფა კაპილარულ ელექტროფორეზსში ციკლოდექსტრინების გამოყენებით ქირალურ სელექტორად

The existences of asymmetric molecules have long been known. Almost half of the drugs currently used in therapy have a chiral center in their molecule. of Currently, the major part of chiral drugs are marketed/sold as racemates, consisting of an equimolar mixture of two enantiomers. Although the enantiomers have the same chemical connectivity of atoms, they exhibit marked differences in their pharmacology, toxicology, parmacokinetics, metabolism, etc. The enantiomers differ in their interactions with enzymes, proteins and receptors. These differences in interactions lead to differences in the biological activities. The understanding of the enantioselectivity of drug action sites is continually evolving, consequently the tendency of marketing pure enantiomers of chiral drugs increases. With this tendency the development of new improved methods for the separation and determination of enantiomers became a permanent necessity and also a challenge.