კაინის მჟავით გამოწვეულ ეპილეფსიაზე რკინის ნანონაწილაკებთან დაკავშირებული ქვერცეტინის მოქმედების ეფექტურობის შესწავლა ვირთაგვებში

The study of effective remedies against neurodegenerative disorders showed neuroprotective nature of flavonoids - an antioxidant of plant origin . Quercetin is one of the widespread representatives of this group and the interest of scientists towards it contributed to numerous biological abilities of Quercetin. Many of its pharmacological effects are known: antiinflammatory, anti-bacterial, anticancer, but the use of Quercetin has been limited due to it poor bioavailability.
The modern approach to solve problem is usage of nanoparticles (NP).
It is shown that nanoparticles protect, control the release and increase the influence of bioactive compounds to the target area.
The goal of the research was in electrophysiological experiment to determine quercetin and q-mnp effects on epileptiform activity, generated by an intra hippocampal application of kainic acid (KA) and the memory disorders due to epileptic status of KA in behavioral experiments.
The experiments were carried out on adult 10-12 week old white laboratory rats. In the rats anesthetized with ketamine and placed in the stereotaxic chamber an epileptiform activity, induced by KA intra hippocampal injection were registered and the effects of preliminary systemic administration into caudal vein on the duration and generation frequency were estimated.
Quercetin/q-mnp effects on behavioral disorders due to KA were also evaluated in the open field and T-maze. The registration and analysis of neuronal activity of the hippocampus were done using a computer program Chart 5.5. The statistical processing of the data obtained was performed using the PRIZM program.