ელანიძე, ლალილალიელანიძეElanidze, LaliLaliElanidze2025-02-182025-02-182022https://openscience.ge/handle/1/7816ჩატარებულია რქაწითელის ჯიშის ყურძნისგან ახალი ტექნოლოგიით დამზადებული ბიოლოგიურად აქტიური დანამატის (ბად) „სანავარდო“ ზოგიერთი ფენოლური კომპონენტის კვლევა. გამოვლენილია მდიდარი და მრავალფეროვანი ფენოლური ნაერთების სპექტრი, რომელიც წარმოდგენილია: საერთო ფენოლების-10გ/ლ; ოლიგომერული პროანტოციანიდინების - 3,2 გ/ლ; პოლიმერული პროანტოციანიდინების -5,1 გ/ლ; კატექინების - 800მგ/ლ; ფენოლმჟავების, მათ შორის: გალის, პროტოკატექის, 4-ოქსიბენზოის, პარა-კუმარის, ფერულის, იასამნის, ვანილინის სახით. ბად-ის ფენოლური კომპონენტები, რომლებიც ხასიათდება მაღალი ბიოლოგიური აქტივობით, განაპირობებს მის ანტიოქსიდანტურ, ანტიბაქტერიულ, ანტივირუსულ, ანტისიმსივმურ, ანტიანთებით მოქმედებას და შესაბამისად, ბად-ის ფუნქციურ დანიშნულებას პრევენციული და სამკურნალო-პროფილაქტიკური თვალსაზრისით.A study was held about some phenolic components of the biologically active additive (BAD) "Sanavardo" that is made from Rkatsiteli grapes on the base of a new technology. A rich and varied spectrum of phenolic compounds has been identified, which are presented in the form of proanthocyanidins (oligomeric and polymeric), common phenols, catechins and phenolic acids. New COVID-19 infection problems proved that the use of natural biologically active compounds and the development of the latest technology for the production of biologically active supplements (BAD) with therapeutic and preventive action are the actual direction of the 21st century. The latest experiments made is clear that phenolic compounds have very strong antioxidant, antibacterial, antiviral effects and various directions of biological influence, those have an effective results on Covid 19 treatment and even in the postcovid syndrome. Grape phenolic substances are characterized as high biologically active in various directions and their content in wines and other products of grape origin is determined in the terms of therapeutic and preventive features. It is experimentally determined that products with a total composition of polyphenols are characterized by synergism of antioxidant activity. On the base of above mentioned items, the new technologies of biologically active supplements of grape origin have been developed. For instance, the "Georgian Vitae rimas XXI" bud that is developed by me that can be named as diverse and rich phenolic spectrum. It can be presented as the form of stilbenoids, catechins, proanthocyanidins, phenolic acids, those are reliable and real source of prevention various diseases, besides it provides number of vital and functional nutrients in food. It also fulfills the body with prominent substances and elements. Studies have shown that even short-term course of proanthocyanidins has a influential effect on the functioning of the vascular system. Proanthocyanidins involves dilation of blood vessels, they can also affect the ongoing processes during oncological diseases, the immune system, the inhibitory effect of procyanidin B4 on the growth and development of breast cancer, and proanthocyanidins even positively effect in reducing atherosclerotic changes and retinopathy development and during diabetes mellitus. Phenolic acids widely distribute form plant compounds that are characterized by high antioxidant activity. The biological activity of phenolic acids reduces the amount of cholesterol in the blood and even inhibits HIV infection. Besides, Phenolic acids have anti-inflammatory, diuretic, anti-tumor effects. Catechins restore blood microcirculation, improve the elasticity of blood vessels, it also has hypocholesterolemic and antiatherosclerotic effects. Anthocyanins have antioxidant and P-vitamin activity and form chelate complexes with metals. Anthocyanidins can also play an important role in reduction of malignant cell proliferation and number of other oncogenic signals. So, we can conclude that it is relevant and important to use grape components during the production of biologically active supplements. The main aim of the research was to investigate some phenolic substances of Bud made from Rkatsiteli grapes with the new technology that is formed by me. "Sanavardo" which is made from Rkatsiteli grapes with new technology was used as the object of the research as the biologically active nutritional supplement. During the experiment the total phenols, oligomeric and polymeric proanthocyanidins, catechins and phenolic acids were determined. The experiment results prove that the bud contain a rich spectrum of phenolic compounds: total phenols - 10g/l; oligomeric proanthocyanidins - 3.2 g/l; Polymeric proanthocyanidins - 5.1 g/l; catechins - 800 mg/l; Phenolic acids, including: gallic, protocatechuic, 4-oxybenzoic, para-coumaric, ferulic, licorice, vanillic. These phenolic compounds are characterized by high antioxidant function and has curative-prophylactic features, in diseases such as: cancer, cardiovascular pathologies, allergies, diabetes, etc. Scientific studies made it clear that biologically active phenolic substances has an important results not only preventing, but also curative-prophylactic function.kaბიოლოგიურად აქტიური დანამატი (ბად)ფენოლური ნაერთებიკატექინებიბიოლოგიური აქტივობაbiologically active additive (BAD)phenolic compoundsoligomeric and polymeric proanthocyanidinscatechinsbiological activitytext::conference output::conference proceedings